Edward Rockenstein Selected Research

Lewy Body Disease (Lewy Body Dementia)

1/2019	Systemic peptide mediated delivery of an siRNA targeting α-syn in the CNS ameliorates the neurodegenerative process in a transgenic model of Lewy body disease.
3/2016	α-Synuclein interferes with the ESCRT-III complex contributing to the pathogenesis of Lewy body disease.
1/2016	Reducing Endogenous α-Synuclein Mitigates the Degeneration of Selective Neuronal Populations in an Alzheimer's Disease Transgenic Mouse Model.
1/2016	α-synuclein conformational antibodies fused to penetratin are effective in models of Lewy body disease.
3/2013	Axonopathy in an α-synuclein transgenic model of Lewy body disease is associated with extensive accumulation of C-terminal-truncated α-synuclein.
11/2012	Role of α-synuclein in adult neurogenesis and neuronal maturation in the dentate gyrus.
4/2011	Passive immunization reduces behavioral and neuropathological deficits in an alpha-synuclein transgenic model of Lewy body disease.
2/2010	Selective molecular alterations in the autophagy pathway in patients with Lewy body disease and in models of alpha-synucleinopathy.
10/2009	Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinson's and Lewy body diseases.
9/2008	Mechanisms of hybrid oligomer formation in the pathogenesis of combined Alzheimer's and Parkinson's diseases.

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Edward Rockenstein Research Topics

Disease

73	Parkinson Disease (Parkinson's Disease) 01/2021 - 03/2002
48	Dementia (Dementias) 01/2021 - 01/2004
44	Alzheimer Disease (Alzheimer's Disease) 01/2020 - 08/2002
41	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2022 - 03/2002
34	Synucleinopathies 01/2022 - 10/2004
23	Multiple System Atrophy 01/2020 - 06/2002
18	Lewy Body Disease (Lewy Body Dementia) 01/2019 - 03/2002
10	Neuroinflammatory Diseases 01/2021 - 09/2012
9	Parkinsonian Disorders (Parkinsonism) 08/2017 - 06/2003
8	Nervous System Diseases (Neurological Disorders) 01/2021 - 01/2003
8	Gliosis 01/2019 - 08/2007
7	Amyloid Plaque 02/2015 - 02/2005
6	Neurocognitive Disorders (Clerambault Syndrome) 01/2017 - 02/2013
5	Cognitive Dysfunction 01/2019 - 08/2007
5	HIV Infections (HIV Infection) 02/2015 - 04/2011
4	Encephalitis (Encephalitis, Rasmussen) 01/2019 - 08/2007
4	Memory Disorders (Memory Loss) 01/2019 - 01/2011
4	Atrophy 11/2018 - 03/2009
4	Tauopathies 01/2018 - 09/2012
3	Neuroblastoma 01/2019 - 06/2003
3	Huntington Disease (Huntington's Disease) 11/2018 - 03/2014
3	Progressive Supranuclear Palsy (Steele Richardson Olszewski Syndrome) 01/2018 - 03/2014
3	Neoplasms (Cancer) 01/2017 - 12/2014
3	Ataxia (Dyssynergia) 09/2015 - 11/2005
3	Mitochondrial Diseases (Mitochondrial Disease) 01/2015 - 01/2003
2	Corticobasal Degeneration 01/2018 - 03/2014
2	Demyelinating Diseases (Demyelinating Disease) 01/2018 - 03/2015
2	Pick Disease of the Brain (Pick's Disease) 01/2018 - 11/2015
2	Infections 01/2017 - 04/2012
2	Inflammation (Inflammations) 01/2016 - 03/2015
2	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 05/2015 - 09/2007
2	Prion Diseases (Transmissible Spongiform Encephalopathies) 04/2012 - 09/2007
2	Neurodevelopmental Disorders 01/2012 - 10/2008
2	Rett Syndrome (Rett's Disorder) 01/2012 - 10/2008

Drug/Important Bio-Agent (IBA)

52	SynucleinsIBA 01/2022 - 06/2003
48	alpha-SynucleinIBA 01/2020 - 03/2002
40	Proteins (Proteins, Gene)FDA Link 01/2022 - 08/2002
20	Amyloid (Amyloid Fibrils)IBA 01/2022 - 03/2003
12	Amyloid beta-PeptidesIBA 01/2019 - 03/2003
11	Peptides (Polypeptides)IBA 01/2019 - 08/2002
10	cerebrolysinIBA 11/2015 - 05/2006
5	Neuroprotective AgentsIBA 11/2018 - 02/2007
5	AntibodiesIBA 08/2017 - 01/2014
5	CytokinesIBA 12/2015 - 01/2014
4	Brain-Derived Neurotrophic Factor (BDNF)IBA 01/2017 - 03/2009
4	Neprilysin (Neutral Endopeptidase)IBA 01/2011 - 03/2003
3	Toll-Like Receptor 2IBA 01/2021 - 10/2015
3	tau Proteins (tau Protein)IBA 01/2019 - 01/2016
3	Phosphotransferases (Kinase)IBA 01/2018 - 12/2014
3	Pharmaceutical PreparationsIBA 12/2015 - 06/2013
3	Nerve Growth Factors (Neurotrophins)IBA 03/2014 - 05/2010
3	PrionsIBA 01/2014 - 04/2012
3	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 08/2012 - 09/2005
3	beta-SynucleinIBA 09/2007 - 08/2002
2	VaccinesIBA 01/2022 - 01/2018
2	Small Interfering RNA (siRNA)IBA 01/2019 - 10/2005
2	UbiquitinIBA 01/2019 - 10/2011
2	Sunitinib (Sutent)FDA Link 01/2017 - 12/2014
2	MicroRNAs (MicroRNA)IBA 01/2017 - 03/2014
2	Lenalidomide (CC 5013)FDA Link 01/2017 - 05/2015
2	Neuropeptide YIBA 01/2016 - 01/2009
2	Human Immunodeficiency Virus ProteinsIBA 01/2016 - 03/2014
2	LigandsIBA 01/2016 - 02/2013
2	Nerve Growth Factor (NGF)IBA 01/2016 - 02/2013
2	NeuropeptidesIBA 11/2015 - 01/2015
2	Serine Proteases (Serine Protease)IBA 09/2015 - 01/2013
2	Complement System Proteins (Complement)IBA 09/2012 - 09/2010
2	EnzymesIBA 08/2012 - 01/2009
2	Peptide Hydrolases (Proteases)FDA Link 01/2011 - 01/2011
2	CholesterolIBA 02/2010 - 08/2006
1	B-Lymphocyte Epitopes (B-Cell Epitope)IBA 01/2022
1	Protein Kinases (Protein Kinase)IBA 01/2020
1	Leukotriene Antagonists (Leukotriene Receptor Antagonists)IBA 01/2020
1	montelukast (Singulair)FDA Link 01/2020
1	Ligases (Synthetase)IBA 01/2019
1	OligonucleotidesIBA 01/2019
1	S-Phase Kinase-Associated Proteins (Skp1 Protein)IBA 01/2019
1	proanthocyanidinIBA 01/2019
1	CalpainIBA 12/2018
1	calpain inhibitorsIBA 12/2018
1	NPT200-11IBA 11/2018
1	Dopamine Plasma Membrane Transport Proteins (Dopamine Transporter)IBA 11/2018
1	Chaperonin Containing TCP-1IBA 11/2018
1	Apolipoproteins B (ApoB)IBA 01/2018
1	AntigensIBA 01/2018
1	Combined VaccinesIBA 01/2018
1	Single-Chain AntibodiesIBA 01/2018
1	GlucansIBA 01/2018
1	Protein Isoforms (Isoforms)IBA 01/2018
1	Immunoglobulin FragmentsIBA 01/2018
1	Sirolimus (Rapamycin)FDA Link 01/2018
1	Endosomal Sorting Complexes Required for TransportIBA 03/2016
1	ImmunophilinsIBA 01/2016
1	penetratinIBA 01/2016
1	CalcineurinIBA 01/2016
1	CalciumIBA 01/2016

Therapy/Procedure

15	Therapeutics 11/2018 - 01/2003
7	Immunotherapy 01/2019 - 07/2014
2	Drug Therapy (Chemotherapy) 12/2019 - 10/2004
1	Injections 01/2019